LIVACT® Granules

Product sheet

  • Image of granule.
    Image of granule.
  • Image of sachet in Japan as of August, 2021.
    Image of sachet in Japan as of August, 2021.
  • Image of pillow (21 sachets inside) in Japan as of August, 2021.
    Image of pillow (21 sachets inside) in Japan as of August, 2021.

(zip JPEG file:304KB)

Product Name LIVACT®
Drug Class Name Branched-Chain Amino Acid Preparation
Category Prescription Drug
Storage Store at temperature below 30℃
Expiration Date 36 months (60 months in Thailand)
Approved Countries and Regions Japan
South Korea
Vietnam
Myanmar
Philippines
Hong Kong
Macau
Thailand
Cambodia
Laos
(As of April 2023)
Dosage Form Granules

 

Product Information

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Q&A

  • Q. Does this product have calories?

    A.

    As one sachet of this product contains 4 g of branched-chain amino acids, it contains 16 kcal/sachet.

    [Supplementary information]
    The amount of energy generated by metabolizing 1 g of amino acids is 4 kcal.

    Prepared in November 2020

  • Q. [1] What is the ground for the daily dosage of 12 g?
    [2] It is specified that this product should be administered at 3 sachets/day without description of dose adjustment as required. Is the product effective when administered at 2 sachets/day?

    A.
    [1] The dose–response study performed during the development stage showed that, among the dosages of 6, 12, and 18 g of BCAA/day, 12 g/day was associated with the highest efficacy and safety.
    [2] Considering that the incidence of adverse drug reactions tended to increase with the increased dosage, it is appropriate to administer this product at 3 sachets/day, and it is not specified that the dosage should be adjusted as required.

    Therefore, no sufficient effect is likely to occur when administered at 2 sachets/day.
    *Note: The dosage of 18 g/day is above the approved dose.

    [Supplementary information]
    In the dose–response study, this product was administered in the 4 dosage groups, including 0 (placebo), 6, 12, and 18 g*/day, for 12 weeks to evaluate albumin level, performance status (PS), and subjective and objective symptoms. The results showed a dose response in increased albumin level: albumin level was significantly more increased in the 12 or 18 g* group than the placebo group. The 12 and 18 g* groups also showed a higher overall improvement rate based on multiple endpoints than the other groups. The incidence rate of adverse drug reactions was higher in the 18 g* group than in the 12 g group. Blood ammonia concentration increased and BUN increased possibly because of the excessive intake of amino acids were reported in the 18 g group. A significantly larger number of subjects in the 18 g*/day group evaluated this product as difficult to take than the other groups1,2).
    Based on the abovementioned results and in view of the ease of taking this product for patients, it was considered appropriate to set the dosage at 12 g.
    *Note: The dosage of 18 g/day is above the approved dose.

    [Supplementary information]
    Considering the changes in the serum albumin level and Fisher's ratio over time, overall improvement as judged by the primary physician, adverse reactions, and ease of taking the product, the optimal dosage of Livact® Granules was set at 12 g of branched-chain amino acids per day2).

    [References/materials]

    1) Yasutoshi Muto, et al.: JJPEN. Vol. 14: No. 3,360-393, 1992
    2) Interview Form of Livact® Granules
    Reference: Livact Granules

    Prepared in November 2020

  • Q. Is there any method to make it easier to take this product?

    A.

    This product may be taken using the following methods: moistening the oral cavity before taking this product; dividing the large amount of granules into two or three, wrap each portion with an oblate membrane, and take each, while avoiding spreading the product in the oral cavity; and taking this product using an oral jelly.
    This product tastes like amino acids (tastes slightly bitter) when it remains in the mouth and the coating comes off.

    Prepared in November 2020

Partners

Vietnam

DKSH Vietnam Co., Ltd.
5th Floor, Viettel Complex, 285 Cach Mang Thang Tam Street, Ward 12, District 10
70000 Ho Chi Minh City Vietnam

Thailand

DKSH (Thailand) Limited.
2106 Sukhumvit Road, Phrakhanong-Tai, Phrakhanong, Bangkok 10260, Thailand

Philippines

Hi-EISAI PHARMACEUTICAL, INC.
Unit2, 22F, Tower 6789
6789 Ayala Avenue, Makati City 1226 Philippines
※Marketed in Philippines as LIVAMIN

Myanmar

DKSH (Myanmar) Ltd.
No.13, Thitsar Road, Yankin Township
Yangon, Myanmar

Cambodia

Ai Ken Pharma (Cambodia) Co., Ltd.
#07, St.NW03, Sangkat Phnom Penh Thmey, Khan Sen Sok, Phnom Penh, Cambodia

Laos

Ai Ken Pharma (Laos) Company Limited
Unit J4, ASEAN MALL, Phonthan Village, Xaysettha District, Vientiane Capital, Laos PDR

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