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Product sheet

LIVACT^® Information

This section describes the characteristics and pharmacological effects of LIVACT® granules.

Video Contents

Q&A

• Q. Does this product have calories?

  A.

  As one sachet of this product contains 4 g of branched-chain amino acids, it contains 16 kcal/sachet.

  [Supplementary information]
  The amount of energy generated by metabolizing 1 g of amino acids is 4 kcal.

  Prepared in November 2020

• Q. [1] What is the ground for the daily dosage of 12 g?
  [2] It is specified that this product should be administered at 3 sachets/day without description of dose adjustment as required. Is the product effective when administered at 2 sachets/day?

  A.

  [1] The dose–response study performed during the development stage showed that, among the dosages of 6, 12, and 18 g of BCAA/day, 12 g/day was associated with the highest efficacy and safety.
  [2] Considering that the incidence of adverse drug reactions tended to increase with the increased dosage, it is appropriate to administer this product at 3 sachets/day, and it is not specified that the dosage should be adjusted as required.
  
  

  Therefore, no sufficient effect is likely to occur when administered at 2 sachets/day.
  *Note: The dosage of 18 g/day is above the approved dose.

  [Supplementary information]
  In the dose–response study, this product was administered in the 4 dosage groups, including 0 (placebo), 6, 12, and 18 g*/day, for 12 weeks to evaluate albumin level, performance status (PS), and subjective and objective symptoms. The results showed a dose response in increased albumin level: albumin level was significantly more increased in the 12 or 18 g* group than the placebo group. The 12 and 18 g* groups also showed a higher overall improvement rate based on multiple endpoints than the other groups. The incidence rate of adverse drug reactions was higher in the 18 g* group than in the 12 g group. Blood ammonia concentration increased and BUN increased possibly because of the excessive intake of amino acids were reported in the 18 g group. A significantly larger number of subjects in the 18 g*/day group evaluated this product as difficult to take than the other groups^1,2).
  Based on the abovementioned results and in view of the ease of taking this product for patients, it was considered appropriate to set the dosage at 12 g.
  *Note: The dosage of 18 g/day is above the approved dose.

  [Supplementary information]
  Considering the changes in the serum albumin level and Fisher's ratio over time, overall improvement as judged by the primary physician, adverse reactions, and ease of taking the product, the optimal dosage of Livact^® Granules was set at 12 g of branched-chain amino acids per day²⁾.

  [References/materials]

  1) Yasutoshi Muto, et al.: JJPEN. Vol. 14: No. 3,360-393, 1992
  2) Interview Form of Livact^® Granules
  Reference: Livact Granules
  

  Prepared in November 2020

• Q. Is there any method to make it easier to take this product?

  A.

  This product may be taken using the following methods: moistening the oral cavity before taking this product; dividing the large amount of granules into two or three, wrap each portion with an oblate membrane, and take each, while avoiding spreading the product in the oral cavity; and taking this product using an oral jelly.
  This product tastes like amino acids (tastes slightly bitter) when it remains in the mouth and the coating comes off.

  Prepared in November 2020

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