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Pharmacological Actions of LIVACT®

Mechanism of promotion of BCAA albumin synthesis

BCAA has been shown to have a pharmacological action to proactively activate the albumin synthesis signal and to increase albumin synthesis, and it is considered to be a mechanism to improve hypoalbuminemia.

Graph titled 'BCAA concentration-dependent promotion of albumin synthesis (in vitro)' showing the relationship between BCAA concentration (0–2 mM) and albumin production (ng/dish). Pink circles with error bars represent data points; a blue trend line indicates increased albumin synthesis with higher BCAA levels. Statistical significance is noted (p<0.05 vs 0 mM, Dunnett’s test). Hepatocytes from Wistar rats were cultured for 6 hours in media containing 0–2 mM BCAA. Data shown as Mean ± S.E.
Bar graph comparing albumin production (ng/dish) under three conditions: control, leucine, and leucine with mTOR inhibitor (rapamycin). Leucine significantly increases albumin production via mTOR activation, while rapamycin suppresses this effect. Hepatocytes from 6-week-old Wistar rats were cultured for 6 hours in media without amino acids, with 2mM leucine, or with 2mM leucine and 25mg/m² rapamycin. The study demonstrates leucine’s role in promoting albumin synthesis in vitro.

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